Reduced dopamine transporter density in the ventral striatum of patients with Parkinson's disease and pathological gambling.
Identifieur interne : 001997 ( Main/Exploration ); précédent : 001996; suivant : 001998Reduced dopamine transporter density in the ventral striatum of patients with Parkinson's disease and pathological gambling.
Auteurs : Roberto Cilia [Canada] ; Ji Hyun Ko ; Sang Soo Cho ; Thilo Van Eimeren ; Giorgio Marotta ; Giovanna Pellecchia ; Gianni Pezzoli ; Angelo Antonini ; Antonio P. StrafellaSource :
- Neurobiology of disease [ 1095-953X ] ; 2010.
English descriptors
- KwdEn :
- Aged, Basal Ganglia (drug effects), Basal Ganglia (metabolism), Binding, Competitive (drug effects), Dopamine (metabolism), Dopamine Plasma Membrane Transport Proteins (antagonists & inhibitors), Dopamine Plasma Membrane Transport Proteins (metabolism), Female, Gambling (metabolism), Gambling (psychology), Humans, Male, Middle Aged, Neostriatum (drug effects), Neostriatum (metabolism), Parkinson Disease (drug therapy), Parkinson Disease (metabolism), Protein Binding (drug effects), Tomography, Emission-Computed, Single-Photon (methods), Tropanes (antagonists & inhibitors), Tropanes (metabolism).
- MESH :
- chemical , antagonists & inhibitors : Dopamine Plasma Membrane Transport Proteins, Tropanes.
- chemical , metabolism : Dopamine, Dopamine Plasma Membrane Transport Proteins, Tropanes.
- drug effects : Basal Ganglia, Binding, Competitive, Neostriatum, Protein Binding.
- drug therapy : Parkinson Disease.
- metabolism : Basal Ganglia, Gambling, Neostriatum, Parkinson Disease.
- methods : Tomography, Emission-Computed, Single-Photon.
- psychology : Gambling.
- Aged, Female, Humans, Male, Middle Aged.
Abstract
Pathological gambling (PG) represents a behavioral side effect of dopamine replacement therapy in a minority of patients with Parkinson's disease (PD). Using striatal dopamine transporter (DAT) with single photon emission tomography we assessed presynaptic dopaminergic function in 8 PD patients with PG, 21 matched PD control subjects, and 14 healthy subjects. Statistical Parametric Mapping was applied for image analysis. The analysis of variance (ANOVA) revealed that the three groups differed in dorsal and ventral striata bilaterally. The post-hoc analysis displayed a reduced tracer binding in the ventral striatum of PD patients with PG compared to PD controls, possibly reflecting either a reduction of mesolimbic projections or, alternatively, a lower membrane DAT expression on presynaptic terminals. The latter hypothesis is most likely given that the functional reduction of presynaptic reuptake would be more consistent with the increased dopamine levels in the ventral striatum recently reported in PD gamblers.
DOI: 10.1016/j.nbd.2010.03.013
PubMed: 20338240
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000D33
- to stream PubMed, to step Curation: 000D33
- to stream PubMed, to step Checkpoint: 000D33
- to stream Ncbi, to step Merge: 000C37
- to stream Ncbi, to step Curation: 000C37
- to stream Ncbi, to step Checkpoint: 000C37
- to stream Main, to step Merge: 001B03
- to stream Main, to step Curation: 001997
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Reduced dopamine transporter density in the ventral striatum of patients with Parkinson's disease and pathological gambling.</title><author><name sortKey="Cilia, Roberto" sort="Cilia, Roberto" uniqKey="Cilia R" first="Roberto" last="Cilia">Roberto Cilia</name><affiliation wicri:level="4"><nlm:affiliation>Toronto Western Research Institute and Hospital, UHN, University of Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto Western Research Institute and Hospital, UHN, University of Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Ko, Ji Hyun" sort="Ko, Ji Hyun" uniqKey="Ko J" first="Ji Hyun" last="Ko">Ji Hyun Ko</name></author><author><name sortKey="Cho, Sang Soo" sort="Cho, Sang Soo" uniqKey="Cho S" first="Sang Soo" last="Cho">Sang Soo Cho</name></author><author><name sortKey="Van Eimeren, Thilo" sort="Van Eimeren, Thilo" uniqKey="Van Eimeren T" first="Thilo" last="Van Eimeren">Thilo Van Eimeren</name></author><author><name sortKey="Marotta, Giorgio" sort="Marotta, Giorgio" uniqKey="Marotta G" first="Giorgio" last="Marotta">Giorgio Marotta</name></author><author><name sortKey="Pellecchia, Giovanna" sort="Pellecchia, Giovanna" uniqKey="Pellecchia G" first="Giovanna" last="Pellecchia">Giovanna Pellecchia</name></author><author><name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name></author><author><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name></author><author><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P" last="Strafella">Antonio P. Strafella</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:20338240</idno><idno type="pmid">20338240</idno><idno type="doi">10.1016/j.nbd.2010.03.013</idno><idno type="wicri:Area/PubMed/Corpus">000D33</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000D33</idno><idno type="wicri:Area/PubMed/Curation">000D33</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000D33</idno><idno type="wicri:Area/PubMed/Checkpoint">000D33</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000D33</idno><idno type="wicri:Area/Ncbi/Merge">000C37</idno><idno type="wicri:Area/Ncbi/Curation">000C37</idno><idno type="wicri:Area/Ncbi/Checkpoint">000C37</idno><idno type="wicri:Area/Main/Merge">001B03</idno><idno type="wicri:Area/Main/Curation">001997</idno><idno type="wicri:Area/Main/Exploration">001997</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Reduced dopamine transporter density in the ventral striatum of patients with Parkinson's disease and pathological gambling.</title><author><name sortKey="Cilia, Roberto" sort="Cilia, Roberto" uniqKey="Cilia R" first="Roberto" last="Cilia">Roberto Cilia</name><affiliation wicri:level="4"><nlm:affiliation>Toronto Western Research Institute and Hospital, UHN, University of Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto Western Research Institute and Hospital, UHN, University of Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Ko, Ji Hyun" sort="Ko, Ji Hyun" uniqKey="Ko J" first="Ji Hyun" last="Ko">Ji Hyun Ko</name></author><author><name sortKey="Cho, Sang Soo" sort="Cho, Sang Soo" uniqKey="Cho S" first="Sang Soo" last="Cho">Sang Soo Cho</name></author><author><name sortKey="Van Eimeren, Thilo" sort="Van Eimeren, Thilo" uniqKey="Van Eimeren T" first="Thilo" last="Van Eimeren">Thilo Van Eimeren</name></author><author><name sortKey="Marotta, Giorgio" sort="Marotta, Giorgio" uniqKey="Marotta G" first="Giorgio" last="Marotta">Giorgio Marotta</name></author><author><name sortKey="Pellecchia, Giovanna" sort="Pellecchia, Giovanna" uniqKey="Pellecchia G" first="Giovanna" last="Pellecchia">Giovanna Pellecchia</name></author><author><name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name></author><author><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name></author><author><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P" last="Strafella">Antonio P. Strafella</name></author></analytic><series><title level="j">Neurobiology of disease</title><idno type="eISSN">1095-953X</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Basal Ganglia (drug effects)</term><term>Basal Ganglia (metabolism)</term><term>Binding, Competitive (drug effects)</term><term>Dopamine (metabolism)</term><term>Dopamine Plasma Membrane Transport Proteins (antagonists & inhibitors)</term><term>Dopamine Plasma Membrane Transport Proteins (metabolism)</term><term>Female</term><term>Gambling (metabolism)</term><term>Gambling (psychology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neostriatum (drug effects)</term><term>Neostriatum (metabolism)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (metabolism)</term><term>Protein Binding (drug effects)</term><term>Tomography, Emission-Computed, Single-Photon (methods)</term><term>Tropanes (antagonists & inhibitors)</term><term>Tropanes (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Dopamine Plasma Membrane Transport Proteins</term><term>Tropanes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term><term>Dopamine Plasma Membrane Transport Proteins</term><term>Tropanes</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Basal Ganglia</term><term>Binding, Competitive</term><term>Neostriatum</term><term>Protein Binding</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Basal Ganglia</term><term>Gambling</term><term>Neostriatum</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Gambling</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pathological gambling (PG) represents a behavioral side effect of dopamine replacement therapy in a minority of patients with Parkinson's disease (PD). Using striatal dopamine transporter (DAT) with single photon emission tomography we assessed presynaptic dopaminergic function in 8 PD patients with PG, 21 matched PD control subjects, and 14 healthy subjects. Statistical Parametric Mapping was applied for image analysis. The analysis of variance (ANOVA) revealed that the three groups differed in dorsal and ventral striata bilaterally. The post-hoc analysis displayed a reduced tracer binding in the ventral striatum of PD patients with PG compared to PD controls, possibly reflecting either a reduction of mesolimbic projections or, alternatively, a lower membrane DAT expression on presynaptic terminals. The latter hypothesis is most likely given that the functional reduction of presynaptic reuptake would be more consistent with the increased dopamine levels in the ventral striatum recently reported in PD gamblers.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><noCountry><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name><name sortKey="Cho, Sang Soo" sort="Cho, Sang Soo" uniqKey="Cho S" first="Sang Soo" last="Cho">Sang Soo Cho</name><name sortKey="Ko, Ji Hyun" sort="Ko, Ji Hyun" uniqKey="Ko J" first="Ji Hyun" last="Ko">Ji Hyun Ko</name><name sortKey="Marotta, Giorgio" sort="Marotta, Giorgio" uniqKey="Marotta G" first="Giorgio" last="Marotta">Giorgio Marotta</name><name sortKey="Pellecchia, Giovanna" sort="Pellecchia, Giovanna" uniqKey="Pellecchia G" first="Giovanna" last="Pellecchia">Giovanna Pellecchia</name><name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P" last="Strafella">Antonio P. Strafella</name><name sortKey="Van Eimeren, Thilo" sort="Van Eimeren, Thilo" uniqKey="Van Eimeren T" first="Thilo" last="Van Eimeren">Thilo Van Eimeren</name></noCountry><country name="Canada"><region name="Ontario"><name sortKey="Cilia, Roberto" sort="Cilia, Roberto" uniqKey="Cilia R" first="Roberto" last="Cilia">Roberto Cilia</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001997 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001997 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:20338240
|texte= Reduced dopamine transporter density in the ventral striatum of patients with Parkinson's disease and pathological gambling.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:20338240" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |